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AZD 7009

CAS No. 864368-79-6

AZD 7009( AZD7009 )

Catalog No. M16266 CAS No. 864368-79-6

AZD 7009 is a novel antiarrhythmic agent that inhibits the late sodium current in CHO K1 cells expressing hNav1.5 with IC50 of 11 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD 7009
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD 7009 is a novel antiarrhythmic agent that inhibits the late sodium current in CHO K1 cells expressing hNav1.5 with IC50 of 11 uM.
  • Description
    AZD 7009 is a novel antiarrhythmic agent that inhibits the late sodium current in CHO K1 cells expressing hNav1.5 with IC50 of 11 uM; also inhibits late sodium current in isolated rabbit atrial and ventricular myocytes, attenuates the E-4031-induced action potential duration prolongation, induces early afterdepolarisations (EADs) in Purkinje fibres.Heart Arrhythmia Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AZD7009
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    864368-79-6
  • Formula Weight
    446.548
  • Molecular Formula
    C23H34N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N1(CC2OC(C1)CN(C2)CCNC(=O)OC(C)(C)C)C[C@@H](COc1ccc(C#N)cc1)O
  • Chemical Name
    tert-butyl N-[2-[3-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]nonan-7-yl]ethyl]carbamate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Goldstein RN, et al. J Cardiovasc Electrophysiol. 2004 Dec;15(12):1444-50. 2. Persson F, et al. J Cardiovasc Electrophysiol. 2005 Mar;16(3):329-41. 3. Persson F, et al. J Cardiovasc Pharmacol. 2005 Jul;46(1):7-17. 4. Persson F, et al. Eur J Pharmacol. 2007 Mar 8;558(1-3):133-43.
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